Gardnerella vaginalis Clade Distribution Is Associated With Behavioral Practices and Nugent Score in Women Who Have Sex With Women

EL Plummer; LA Vodstrcil; GL Murray; CK Fairley; JA Danielewski; SM Garland; EPF Chow; DM Bulach; KA Fethers; JS Hocking; CS Bradshaw

Journal article

Gardnerella vaginalis Clade Distribution Is Associated With Behavioral Practices and Nugent Score in Women Who Have Sex With Women

EL Plummer, LA Vodstrcil, GL Murray, CK Fairley, JA Danielewski, SM Garland, EPF Chow, DM Bulach, KA Fethers, JS Hocking, CS Bradshaw

Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2020

DOI: 10.1093/infdis/jiz474

Abstract

BACKGROUND: Gardnerella vaginalis is detected in women with and without bacterial vaginosis (BV). Identification of 4 G. vaginalis clades raised the possibility that pathogenic and commensal clades exist. We investigated the association of behavioral practices and Nugent Score with G. vaginalis clade distribution in women who have sex with women (WSW). METHODS: Longitudinal self-collected vaginal specimens were analyzed using established G. vaginalis species-specific and clade-typing polymerase chain reaction assays. Logistic regression assessed factors associated with detection of G. vaginalis clades, and multinomial regression assessed factors associated with number of clades. RESULTS: Cla..

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University of Melbourne Researchers

Erica Plummer Author

Lenka Vodstrcil Author

Gerald Murray Author

Suzanne Wark Author

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Grants

Awarded by Australian National Health and Medical Research Council

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work funded by The Australian National Health and Medical Research Council Project Grant (1020457; to C. S. B.) and the Australian National Health and Medical Research Council Program Grant (1071269; to S. M. G. and C. K. F.). E. L. P. was supported by an Australian Government Research Training Program Scholarship.